Dragonbone Protectors can drop your Hit-Points in one single hit, so watch out, and beware! If you have a high enough Prayer "Soulspit" level they won't attack you first but if your Prayer "Soulspit" level is low they will attack you first.
You get to Dragonbone Protectors by using the Boss Teleport System or by typing ::dragonbone
The best way to kill Dragonbone Protectors is to use prayer "Soulspit" (Level 93 or higher recommended). You will need a fast hitting weapon, such as a Glock, Ice katana, or an Assault rifle. You're going to need armor, such as Wolverine Torva, Flame Pernix, Dragonbone Melee armor, or higher/better armor. Another recommendation is White Glass Wings to help keep your prayer "Soulspit" at max and to bring prayer potions.
If your prayer "Soulspit" level is NOT at least 92 but you want to kill Dragonbone Portectors, you can by bring lots of food (Rocktail or Shark) and prayer potions. But do keep in mind you will have a higher chance of dying. (you won't lose your items if you die)